Sequencing the Genes of Dogs with Acute Myeloid Leukemia

Oncology
Observational
ENROLLING

Overview

Help us find new treatments for AML

Complete the registration form to find out if your pet qualifies to be in our clinical trial.

Acute myeloid leukemia is a cancer of the blood. Although uncommon, it is a highly aggressive form of cancer and often kills dogs quickly, particularly because we don’t have many drugs that we can use to treat the leukemia. Great strides have been made in humans with acute myeloid leukemia, which is similar to the disease we see in dogs. However, unlike humans, we know very little about the genetic mutations that underlie acute myeloid leukemia in dogs, which is the goal of this study

Owner Responsibilities

You will be asked to allow us to collect a small amount of additional blood and a mouth swab for DNA.

You will be asked to allow us to collect a small amount of additional blood and a mouth swab for DNA. There are no further obligations or responsibilities.

Compensation

The grant will cover the cost of specific tests (such as flow cytometry) to confirm the diagnosis of acute myeloid leukemia.

The grant will cover the cost of specific tests (such as flow cytometry) to confirm the diagnosis of acute myeloid leukemia.

Location

Cornell

ITHACA NY

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Location

Cornell University Hospital for Animals (CUHA)

930 Campus Rd,

Ithaca, NY 14853

Study Team

Carol Frederick
Carol FrederickClinical Trials Coordinator

Carol graduated from SUNY Delhi in 1994 and became an LVT. She spent 2 years in private practice, then moved to the emergency and critical care department at Cornell University Hospital for Animals. She obtained her technician specialty in ECC in 2007. After 21 years in ECC she moved to clinical trials, and now is the lead trials coordinator at Cornell.

Apply today if...

This is a sample-collection only study for dogs with acute leukemia

Dogs diagnosed with acute leukemia are eligible to participate.

Acute Myeloid Leukemia

Acute myeloid leukemia is a cancer of the blood. Although uncommon, it is a highly aggressive form of cancer and often kills dogs quickly, particularly because we don’t have many drugs that we can use to treat the leukemia. Great strides have been made in humans with acute myeloid leukemia, which is similar to the disease we see in dogs.

New treatments have been developed for people with acute myeloid leukemia, patients live longer with the disease than they used to (most people usually died from the disease within 3 years of diagnosis), and the disease can be more accurately divided into subtypes, which provide better information on treatment and prognosis. In fact, treatments are often tailored to the specific subtype of leukemia in the patient, which is now called precision medicine. All of these improvements in the diagnosis, treatment and prognostication of acute myeloid leukemia in humans have been made possible by genetic testing and identification of specific genetic defects or mutations that are responsible for the tumor.

However, unlike humans, we know very little about the genetic mutations that underlie acute myeloid leukemia in dogs, which is the goal of this study. In a multi-institutional study involving blood cancer specialists in veterinary and human medicine, we will perform in-depth genetic analysis of 50 dogs with acute myeloid leukemia by sequencing the genes within the tumor. Relevant genetic mutations will be identified by comparing gene sequences of the cancer cells to those of normal tissue, which we will retrieve from standard mouth swabs. From this genetic analysis, we hope to identify mutations in acute myeloid leukemia in dogs that would be responsive to newer treatments or that we could target for development of new drugs. We also hope to more accurately classify dogs into subtypes, which would help us better inform owners of prognosis and treat the dogs with more appropriate therapy, thereby prolonging their life, just like we have in humans. 

About Acute Myeloid Leukemia

Acute myeloid leukemia is a cancer of the blood. Although uncommon, it is a highly aggressive form of cancer and often kills dogs quickly, particularly because we don’t have many drugs that we can use to treat the leukemia. Great strides have been made in humans with acute myeloid leukemia, which is similar to the disease we see in dogs.

New treatments have been developed for people with acute myeloid leukemia, patients live longer with the disease than they used to (most people usually died from the disease within 3 years of diagnosis), and the disease can be more accurately divided into subtypes, which provide better information on treatment and prognosis. In fact, treatments are often tailored to the specific subtype of leukemia in the patient, which is now called precision medicine. All of these improvements in the diagnosis, treatment and prognostication of acute myeloid leukemia in humans have been made possible by genetic testing and identification of specific genetic defects or mutations that are responsible for the tumor.

However, unlike humans, we know very little about the genetic mutations that underlie acute myeloid leukemia in dogs, which is the goal of this study. In a multi-institutional study involving blood cancer specialists in veterinary and human medicine, we will perform in-depth genetic analysis of 50 dogs with acute myeloid leukemia by sequencing the genes within the tumor. Relevant genetic mutations will be identified by comparing gene sequences of the cancer cells to those of normal tissue, which we will retrieve from standard mouth swabs. From this genetic analysis, we hope to identify mutations in acute myeloid leukemia in dogs that would be responsive to newer treatments or that we could target for development of new drugs. We also hope to more accurately classify dogs into subtypes, which would help us better inform owners of prognosis and treat the dogs with more appropriate therapy, thereby prolonging their life, just like we have in humans. 

FAQs

Know before you register

What is a clinical trial?

What is informed consent?

What are my rights as a research participant?

What should I consider before agreeing to have my pet participate?

What questions should I ask before signing up for a clinical trial?

Will it cost me anything to take part in a research study?

How is my pet protected from injury in a study or a trial?

How are research subjects protected?

Do research participants get paid?

After the study is over can I continue to receive the study medication?

What is a randomized trial?

If I withdraw my pet from a randomized trial, will I be told if they received the placebo (an inactive, dummy pill) or the active drug?

What is a clinical trial?

Doctors and scientists take part in many kinds of research studies. Clinical research helps researchers understand how best to treat patients or helps them learn more about a particular condition or disease. There are many different forms of clinical research. One common form is a clinical trial. In a clinical trial, researchers test new drugs, medical devices or treatments.

Clinical trials may seek to discover new drugs, new ways of giving patients approved drugs, new combinations of approved drugs, new surgical techniques, devices, or biological products. Clinical trials are also conducted to test cutting-edge and novel therapies, like studies that involve gene therapy or gene transfer.

What is informed consent?

Informed consent is a process that helps you learn about the research study. After learning about the study, you will be able to ask the researcher or his/her staff questions. You should only agree to take part after you clearly understand the study and feel comfortable. You should take time to talk over your decision with your doctors, family, and friends. If you agree to take part, you will be asked to sign an "informed consent form."

What are my rights as a research participant?

  • You have the right to not take part in a research study.
  • You have the right to drop out at anytime.
  • You have the right to be given new information about the study.
  • You have the right to ask questions at any time and have them answered as soon as possible.
  • You also have the responsibility to stay informed during your participation in a study. You should ask questions about anything you do not understand or simply want to know.

What should I consider before agreeing to have my pet participate?

You may consider having your pet participate in a study because:

  • They may benefit from the best possible treatment or an experimental treatment that would otherwise not be available.
  • The veterinarians and technicians will closely monitor your pet’s progress throughout the trial.
  • You would be helping researchers to improve the treatments for future patients.

You might consider not taking part in a study because:

  • The experimental treatment may not work for your pet, or it could make your condition worse.
  • The experimental treatment may cause side effects that no one anticipated.
  • If the trial is randomized and includes a placebo (an inactive, dummy pill), your pet may not be given the experimental treatment.
  • The amount of testing for efficacy and safety purposes may involve too many trips to the research office and take too much time.

There is no guarantee that a clinical trial will help your pet’s condition, but the results will contribute to knowledge that may make a difference in the future care of patients.

What questions should I ask before signing up for a clinical trial?

  • If my pet is ill, will this research help them?
  • What are the risks?
  • What is involved? What will I have to do?
  • Will I be charged anything or compensated for my participation?
  • How can I end my participation if I change my mind?
  • What will happen when the study is over? Will I be told the results?
  • Is the study controversial?
  • Whom do I contact to express concerns or obtain information?

Will it cost me anything to take part in a research study?

Clinical trials test new drugs, devices, or treatments. In some cases, taking part will not cost you anything. In other studies, the research team may bill you for drugs, devices, and services they provide. The study informed consent form will describe any costs to you in detail. If the information in the consent form is not clear, you should ask the research team to explain any costs before you sign the consent form.

How is my pet protected from injury in a study or a trial?

Your pet is protected first and foremost by being told honestly and without bias what the known and potential risks are for participating in the trial. This information will be submitted to you in a language you will be able to understand. There is an Institutional Review Board (IRB) requirement that every participant in a clinical trial be informed about the possible risks, benefits and available alternatives. All of the information necessary to assist you in determining whether or not your pet should participate in a clinical trial is provided in a document called the "informed consent document." This document informs you of how to let the investigator know if you think your pet is experiencing a problem with the research and what resources are available to help you. You should ask any questions you may have about a clinical trial before signing the informed consent document. Even after you have signed the informed consent document to have your pet participate in a clinical trial, you should always speak to the investigator if you have questions or problems.

How are research subjects protected?

The Institutional Review Board (IRB) protects people and animals in research studies. The IRB includes scientists, non-scientists, and community members. The IRB reviews, approves, and monitors all in which pets take part. This oversight keeps risks to research participants as low as possible. The IRB also keeps track of ongoing studies to make sure they are being done in the right way.

Do research participants get paid?

This varies by study and will be covered in your Informed Consent Document.

After the study is over can I continue to receive the study medication?

Generally, participation ends when the study ends because it might not be safe or effective to continue treatment based on what is known at the time. Sometimes patients can remain on the study drug if they are responding to the new treatment; however, this is the exception rather than the rule.

What is a randomized trial?

Randomized is used to describe a research study that hopes to compare two or more different treatments or procedures. Randomized means that your pet will be assigned to a study group by chance, like flipping a coin.

If I withdraw my pet from a randomized trial, will I be told if they received the placebo (an inactive, dummy pill) or the active drug?

Most randomized trials will only disclose this kind of information when the study has been completely finalized; this is done to protect the integrity of the research data and results. If the trial is a "double-blind" trial, the doctor will not even know which substance your pet received. Most protocols will have information with respect to when a study will be "unblinded." If this is something that you want to know more about, ask the investigator what the study's policy is before you agree to participate.