Overview
Help us evaluate a treatment for Canine Osteosarcoma
Complete the registration form to find out if your pet qualifies to be in our clinical trial.
Compensation
Laverdia-CA1 Free of Charge
Sponsor will cover some of the costs:
$150 per carboplatin visit (up to $600 total)
$25 Per bloodwork visit (up to $100 total)
10% discount on vet visit cost
This study is sponsored by the Cornell Margaret and Richard Riney Canine Health Center. Laverdia-CA1 (verdinexor) will be provided free of charge. The sponsor will cover some of the costs you incur during carboplatin treatment. This will include $150 at each carboplatin visit (up to $600 total) and $25 at each bloodwork visit (up to $100 total). You will receive a 10% discount on your bill. You are responsible for all additional costs. Any tests or procedures unrelated to the study are your responsibility.
Owner Responsibilities
Administer medication as directed
Return to CUHA for follow-up appointments
This is a 12 week study. You are responsible for administering study medications as directed and must return your dog to CUHA for follow-up appointments according to a specific timeline. All study procedures, time requirements, and responsibilities will be provided to you in a project outline.
Location
Location
Cornell University Hospital for Animals (CUHA)
930 Campus Rd,
Ithaca, NY 14853
Study Team

Carol graduated from SUNY Delhi in 1994 and became an LVT. She spent 2 years in private practice, then moved to the emergency and critical care department at Cornell University Hospital for Animals. She obtained her technician specialty in ECC in 2007. After 21 years in ECC she moved to clinical trials, and now is the lead trials coordinator at Cornell.
Apply today if...
Patients must have been previously treated at Cornell University Hospital for Animals
Patients must had been diagnosed with osteosarcoma and had limb amputation at Cornell University Hospital for Animals previously.
Patients must not have received chemotherapy treatment previously
Background
Osteosarcoma (OS) accounts for 80% to 90% of canine primary bone tumors. Although rare in the canine population, the rate outnumbers that of the human population, with a lifetime incidence risk about 30 to 50 times higher within the overall canine population. Breed-specific incidence rates of OS differ largely, and estimates within certain breeds even show a lifetime risk exceeding 10%, thereby affecting a substantial number of these dogs. Most commonly, OS is diagnosed in middle-aged to older dogs, with a median age of 7 yr. It is well-recognized that giant and large breed dogs are at increased risk of developing OS; however, body size alone cannot explain the variation in incidence between different breeds of dogs, as the risk appears to differ extensively among certain breeds of similar body size.
Causes
Several studies have demonstrated similarities between canine and human OS at the molecular level by showing comparable expression of different proteins.
Diagnosis
Diagnosis is based on biopsy results obtained from affected tissues.
Treatment
No preventative measures are currently available. Median survival time for dogs with primary bone cancer of the appendicular skeleton, treated with surgery and chemotherapy, ranges from 5 to 13 months provided there are no visible metastasis at the time of diagnosis, in which case median survival time drops to about 2 months.
About Osteosarcoma
Osteosarcoma (OS) accounts for 80% to 90% of canine primary bone tumors. Although rare in the canine population, the rate outnumbers that of the human population, with a lifetime incidence risk about 30 to 50 times higher within the overall canine population. Breed-specific incidence rates of OS differ largely, and estimates within certain breeds even show a lifetime risk exceeding 10%, thereby affecting a substantial number of these dogs. Most commonly, OS is diagnosed in middle-aged to older dogs, with a median age of 7 yr. It is well-recognized that giant and large breed dogs are at increased risk of developing OS; however, body size alone cannot explain the variation in incidence between different breeds of dogs, as the risk appears to differ extensively among certain breeds of similar body size.
Several studies have demonstrated similarities between canine and human OS at the molecular level by showing comparable expression of different proteins.
Diagnosis is based on biopsy results obtained from affected tissues.
No preventative measures are currently available. Median survival time for dogs with primary bone cancer of the appendicular skeleton, treated with surgery and chemotherapy, ranges from 5 to 13 months provided there are no visible metastasis at the time of diagnosis, in which case median survival time drops to about 2 months.
FAQs
What is a clinical trial?
What is informed consent?
What are my rights as a research participant?
What should I consider before agreeing to have my pet participate?
What questions should I ask before signing up for a clinical trial?
Will it cost me anything to take part in a research study?
How is my pet protected from injury in a study or a trial?
How are research subjects protected?
Do research participants get paid?
After the study is over can I continue to receive the study medication?
What is a randomized trial?
If I withdraw my pet from a randomized trial, will I be told if they received the placebo (an inactive, dummy pill) or the active drug?
What is a clinical trial?
Doctors and scientists take part in many kinds of research studies. Clinical research helps researchers understand how best to treat patients or helps them learn more about a particular condition or disease. There are many different forms of clinical research. One common form is a clinical trial. In a clinical trial, researchers test new drugs, medical devices or treatments.
Clinical trials may seek to discover new drugs, new ways of giving patients approved drugs, new combinations of approved drugs, new surgical techniques, devices, or biological products. Clinical trials are also conducted to test cutting-edge and novel therapies, like studies that involve gene therapy or gene transfer.
What is informed consent?
Informed consent is a process that helps you learn about the research study. After learning about the study, you will be able to ask the researcher or his/her staff questions. You should only agree to take part after you clearly understand the study and feel comfortable. You should take time to talk over your decision with your doctors, family, and friends. If you agree to take part, you will be asked to sign an "informed consent form."
What are my rights as a research participant?
- You have the right to not take part in a research study.
- You have the right to drop out at anytime.
- You have the right to be given new information about the study.
- You have the right to ask questions at any time and have them answered as soon as possible.
- You also have the responsibility to stay informed during your participation in a study. You should ask questions about anything you do not understand or simply want to know.
What should I consider before agreeing to have my pet participate?
You may consider having your pet participate in a study because:
- They may benefit from the best possible treatment or an experimental treatment that would otherwise not be available.
- The veterinarians and technicians will closely monitor your pet’s progress throughout the trial.
- You would be helping researchers to improve the treatments for future patients.
You might consider not taking part in a study because:
- The experimental treatment may not work for your pet, or it could make your condition worse.
- The experimental treatment may cause side effects that no one anticipated.
- If the trial is randomized and includes a placebo (an inactive, dummy pill), your pet may not be given the experimental treatment.
- The amount of testing for efficacy and safety purposes may involve too many trips to the research office and take too much time.
There is no guarantee that a clinical trial will help your pet’s condition, but the results will contribute to knowledge that may make a difference in the future care of patients.
What questions should I ask before signing up for a clinical trial?
- If my pet is ill, will this research help them?
- What are the risks?
- What is involved? What will I have to do?
- Will I be charged anything or compensated for my participation?
- How can I end my participation if I change my mind?
- What will happen when the study is over? Will I be told the results?
- Is the study controversial?
- Whom do I contact to express concerns or obtain information?
Will it cost me anything to take part in a research study?
Clinical trials test new drugs, devices, or treatments. In some cases, taking part will not cost you anything. In other studies, the research team may bill you for drugs, devices, and services they provide. The study informed consent form will describe any costs to you in detail. If the information in the consent form is not clear, you should ask the research team to explain any costs before you sign the consent form.
How is my pet protected from injury in a study or a trial?
Your pet is protected first and foremost by being told honestly and without bias what the known and potential risks are for participating in the trial. This information will be submitted to you in a language you will be able to understand. There is an Institutional Review Board (IRB) requirement that every participant in a clinical trial be informed about the possible risks, benefits and available alternatives. All of the information necessary to assist you in determining whether or not your pet should participate in a clinical trial is provided in a document called the "informed consent document." This document informs you of how to let the investigator know if you think your pet is experiencing a problem with the research and what resources are available to help you. You should ask any questions you may have about a clinical trial before signing the informed consent document. Even after you have signed the informed consent document to have your pet participate in a clinical trial, you should always speak to the investigator if you have questions or problems.
How are research subjects protected?
The Institutional Review Board (IRB) protects people and animals in research studies. The IRB includes scientists, non-scientists, and community members. The IRB reviews, approves, and monitors all in which pets take part. This oversight keeps risks to research participants as low as possible. The IRB also keeps track of ongoing studies to make sure they are being done in the right way.
Do research participants get paid?
This varies by study and will be covered in your Informed Consent Document.
After the study is over can I continue to receive the study medication?
Generally, participation ends when the study ends because it might not be safe or effective to continue treatment based on what is known at the time. Sometimes patients can remain on the study drug if they are responding to the new treatment; however, this is the exception rather than the rule.
What is a randomized trial?
Randomized is used to describe a research study that hopes to compare two or more different treatments or procedures. Randomized means that your pet will be assigned to a study group by chance, like flipping a coin.
If I withdraw my pet from a randomized trial, will I be told if they received the placebo (an inactive, dummy pill) or the active drug?
Most randomized trials will only disclose this kind of information when the study has been completely finalized; this is done to protect the integrity of the research data and results. If the trial is a "double-blind" trial, the doctor will not even know which substance your pet received. Most protocols will have information with respect to when a study will be "unblinded." If this is something that you want to know more about, ask the investigator what the study's policy is before you agree to participate.