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All Studies (8)

Showing 1-8 of 8 Trials
University of Florida
University of Florida
Canine
Cardiovascular
Interventional
1 Location

DCM in Dobermans

University of Florida
Canine
Cardiovascular
Interventional
1 Location

Dilated Cardiomyopathy (DCM) is a disease of heart muscle that results in a decreased ability of the heart to pump blood. The prognosis for DCM is often poor, with a less than 50% survival rate one year after clinical signs develop, unless a reversible underlying cause is identified. There is no available cure for Dilated Cardiomyopathy, current techniques focus on extending survival time as long as possible. However the focus of this clinical trial is to evaluate a potential curative treatment for cardiomyopathy in the Doberman Pinscher.

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DCM in Dobermans
Your dog has been diagnosed with dilated cardiomyopathy
  • A diagnosis of DCM and previous evidence of congestive heart failure which has been controlled with medical management.
  • A circulating neutralizing antibody titer to the virus vector of less than 1:20
  • Owner agreement to authorize participation with informed consent and collection of the heart following euthanasia or death from any cause.


Your dog has no other heart conditions
  • Clear of extra-cardiac disease, congenital heart disease or primary mitral valvular disease


Anivive Lifesciences
Anivive Lifesciences
Canine
Oncology
Interventional
5 Locations

Canine Lymphoma

Anivive Lifesciences
Canine
Oncology
Interventional
5 Locations

Lymphoma is one of the most commonly encountered cancers in the dog. The incidence of canine lymphoma has steadily increased with approximately 84 per 10,000 dogs diagnosed each year. This randomized, double-masked, placebo-controlled, GCP pivotal field study is evaluating the effectiveness and safety of verdinexor for the treatment of naïve or first relapse stages II, III and IV lymphoma in client owned dogs. Diagnosis of lymphoma must be confirmed by cytology or biopsy for the dog to be eligible for this study. Dogs will be randomized to receive the investigational veterinary product or a placebo treatment (tablets) to be administered with food twice weekly at least 72 hours apart for 8 weeks. After receiving treatment in-hospital on Day 0, the dog will be required to return to the study site on Days 7, 14, 28, 42, and 56 for follow up evaluation visits. Owners will be required to report and record abnormal daily observations and dosing using a phone app at home throughout the study.

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Canine Lymphoma
Your dog has naïve or first relapse lymphoma
  • Naïve: dog who has not received any treatment for lymphoma.

  • First relapse: dog has failed a single round of any chemotherapy completed at least 14-days prior to study entry and has recovered from any acute toxicity from prior chemotherapy or is on prednisone and has exhibited progressive disease.



Your dog is over 1 year old and weighs more than 9kgs (~20lbs)

Your dog is ≥ 1 year, weighs ≥ 9 kg and has a life expectancy of at least 28 days.



Your dog has a diagnosis of lymphoma

Your dog has a diagnosis of lymphoma by cytology (fine needle aspirate of the lymph node) and/or histopathology (biopsy)



Cornell
Cornell
Canine
Oncology
Interventional
1 Location

Investigating a New Treatment for Hemangiosarcoma

Cornell
Canine
Oncology
Interventional
1 Location

Hemangiosarcoma is the most common splenic cancer diagnosed in dogs. The standard of care treatment is splenectomy (surgery) followed by doxorubicin chemotherapy, but long-term survival remains poor. We are continuously looking for additional well-tolerated treatments that may prolong survival for dogs with this disease.

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Investigating a New Treatment for Hemangiosarcoma
Your dog has had a splenic Hemangiosarcoma
Your dog must have a splenic hemangiosarcoma that has been surgically removed either at a local veterinarian or at the CUHA. The diagnosis must have been confirmed with histopathology.

Exclusionary criteria

Your dog must not be on any supplements such as Yunnan baiyao or I'm Yunity/turkey tail mushroom.

Your dog must not have evidence of metastasis (spread of disease).



Cornell
Cornell
Feline
Interventional
1 Location

Dietary Trial for Cats with IBD or GI Lymphoma

Cornell
Feline
Interventional
1 Location

The clinical signs in some cats with chronic enteropathy (chronic vomiting and/or diarrhea) can be reversed with dietary management using a specially formulated diet. It is not clear why some cats respond to diet, or what the optimal composition of the diet for cats with chronic enteropathy should be. We want to know if diets containing proteins that are selected to minimize immune responses and fortified in Vitamin B12 and natural anti-inflammatory agents (prebiotics and curcumin) are better than conventional diets for cats with chronic enteropathy.

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Dietary Trial for Cats with IBD or GI Lymphoma
Any Cat with signs of chronic GI disease

Your cat must have signs of chronic GI disease (of more than 3 weeks duration), have had non-GI causes of vomiting and/or diarrhea ruled out, and must be amenable to blood sampling at the times required by the study.

Your cat must currently be symptomatic.



Cornell
Cornell
Canine
Observational
1 Location

Sequencing the Genes of Dogs with Acute Myeloid Leukemia

Cornell
Canine
Observational
1 Location

Acute myeloid leukemia is a cancer of the blood. Although uncommon, it is a highly aggressive form of cancer and often kills dogs quickly, particularly because we don’t have many drugs that we can use to treat the leukemia. Great strides have been made in humans with acute myeloid leukemia, which is similar to the disease we see in dogs. However, unlike humans, we know very little about the genetic mutations that underlie acute myeloid leukemia in dogs, which is the goal of this study

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Sequencing the Genes of Dogs with Acute Myeloid Leukemia
This is a sample-collection only study for dogs with acute leukemia

Dogs diagnosed with acute leukemia are eligible to participate.



Cornell
Cornell
Canine
Interventional
1 Location

Selective Inhibition of Nuclear Export (SINE) and Canine Osteosarcoma

Cornell
Canine
Interventional
1 Location

Osteosarcoma is a common cancer diagnosed in dogs, particularly in large breed dogs. While several chemotherapy protocols have been shown to provide modest management of the onset of metastasis (spread of cancer), we are continuously looking for additional treatments that may extend survival time. Carboplatin is a widely accepted chemotherapy agent used in treatment of osteosarcoma. The results of this study will allow us to determine if dogs can successfully tolerate carboplatin and a new drug called Laverdia-CA1 (verdinexor) in a combination protocol.

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Selective Inhibition of Nuclear Export (SINE) and Canine Osteosarcoma
Your dog has been seen by CUHA

Patients must have been previously treated at Cornell University Hospital for Animals



Your dog has had limb amputation due to osteosarcoma

Patients must had been diagnosed with osteosarcoma and had limb amputation at Cornell University Hospital for Animals previously.



You dog has NOT received any chemotherapy

Patients must not have received chemotherapy treatment previously



Midwestern University
Midwestern University
Canine
Observational
1 Location

Performance of a New Point-of-care Rapid Test to Diagnose Pulmonary Coccidioidomycosis

Midwestern University
Canine
Observational
1 Location

Diagnosis of coccidioidomycosis in dogs is challenging due to the fact that the symptoms are not specific for this disease. Coccidioidomycosis can be diagnosed via a biopsy however the most common method is testing for antibodies to the fungus. These tests are often sent to third party labs delaying confirmation of the disease. This study looks to evaluate a potential point of care rapid test which would be able to provide a positive or negative result indicating the presence or absence of antibodies, respectively, within 30-60 minutes. The diagnosis of pulmonary coccidioidomycosis can be difficult because clinical signs overlap with many other respiratory tract disorders and dogs can have positive Valley Fever antibody titers without active clinical infection. Acute phase proteins are useful biomarkers for many other disorders and our hope is to determine whether they can facilitate making a diagnosis of pulmonary coccidioidomycosis in dogs. For additional details or questions please contact Dr. Jaffey ([email protected]).

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Performance of a New Point-of-care Rapid Test to Diagnose Pulmonary Coccidioidomycosis
Your dog has a a confirmed or suspected novel diagnosis of pulmonary coccidioidomycosis

Your dog has a a confirmed or suspected novel diagnosis of pulmonary coccidioidomycosis



Your dog has at least 1 respiratory sign

Your dog has one of the following respiratory signs:

  • Cough

  • Exercise intolerance

  • Wheezing

  • Dyspnea

  • Tachypnea

  • Respiratory distress



Your dog has not received an anti-fungal treatment more than 7 days before enrollment

Dog must not have received an anti-fungal treatment for more than 7 days before enrollment



Midwestern University
Midwestern University
Canine
Interventional
1 Location

Efficacy of twice-daily nebulized budesonide for the treatment of canine chronic bronchitis: a pilot study

Midwestern University
Canine
Interventional
1 Location

Canine chronic bronchitis is an inflammatory disease characterized by a cough for > 2 months without another identifiable cause. Dogs with chronic bronchitis have persistent airway neutrophilic inflammation. The foundation of long-term therapy is corticosteroids. Oral prednisone is commonly used but has a litany of possible adverse effects. Inhaled steroids is an alternative to avoid the adverse effects of prednisone but the only available option is fluticasone. This medication is expensive and has variable efficacy. Inhaled budesonide is a medication used in humans to treat a similar airway disorder and is a fraction of the cost. This study aims to investigate the benefit of inhaled budesonide on respiratory tract symptoms in dogs with chronic bronchitis.

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Efficacy of twice-daily nebulized budesonide for the treatment of canine chronic bronchitis: a pilot study
Your dog has a chronic cough for longer than 2 months

Dogs with a history of cough exceeding two months may be eligible for the study.



Your dog has thoracic radiographs performed in the past 3 months

Thoracic radiographs will be used by principal investigator to determine eligibility.



Your dog does NOT have an alternative cause for chronic cough

Dogs with alternative caused for chronic cough such as tracheal collapse, heart disease, cancer, Valley Fever, etc are not eligible for this study.



Your dog has not received previous treatment with corticosteroids

Dogs who have received previously received corticosteroids for treatment of chronic cough are not eligible for this study.