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All Studies (9)

Showing 1-9 of 9 Trials
University of Florida
University of Florida
Canine
Endocrine/Metabolic
Observational
1 Location

Canine Diabetes

University of Florida
Canine
Endocrine/Metabolic
Observational
1 Location

Diabetes mellitus is an important health problem in both dogs and people. Type 1 diabetes (T1D) in people is caused by an attack of the body’s own immune system on cells in the pancreas. Diabetes in dogs is thought to be similar in some ways to T1D in people, but there is still much more to learn about the causes of diabetes in dogs as well as better ways to prevent and treat the disease. The purpose of this study is to learn more about metabolism and immune function in diabetic dogs.

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Canine Diabetes
University of Florida
University of Florida
Canine
Cardiovascular
Interventional
1 Location

DCM in Dobermans

University of Florida
Canine
Cardiovascular
Interventional
1 Location

Dilated Cardiomyopathy (DCM) is a disease of heart muscle that results in a decreased ability of the heart to pump blood. The prognosis for DCM is often poor, with a less than 50% survival rate one year after clinical signs develop, unless a reversible underlying cause is identified. There is no available cure for Dilated Cardiomyopathy, current techniques focus on extending survival time as long as possible. However the focus of this clinical trial is to evaluate a potential curative treatment for cardiomyopathy in the Doberman Pinscher.

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DCM in Dobermans
Anivive Lifesciences
Anivive Lifesciences
Canine
Oncology
Interventional
11 Locations

Canine Lymphoma

Anivive Lifesciences
Canine
Oncology
Interventional
11 Locations

Lymphoma is one of the most commonly encountered cancers in the dog. The incidence of canine lymphoma has steadily increased with approximately 84 per 10,000 dogs diagnosed each year. This randomized, double-masked, placebo-controlled, GCP pivotal field study is evaluating the effectiveness and safety of verdinexor for the treatment of naïve or first relapse stages II, III and IV lymphoma in client owned dogs. Diagnosis of lymphoma must be confirmed by cytology or biopsy for the dog to be eligible for this study. Dogs will be randomized to receive the investigational veterinary product or a placebo treatment (tablets) to be administered with food twice weekly at least 72 hours apart for 8 weeks. After receiving treatment in-hospital on Day 0, the dog will be required to return to the study site on Days 7, 14, 28, 42, and 56 for follow up evaluation visits. Owners will be required to report and record abnormal daily observations and dosing using a phone app at home throughout the study.

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Canine Lymphoma
Cornell
Cornell
Canine
Oncology
Interventional
1 Location

Investigating a New Treatment for Hemangiosarcoma

Cornell
Canine
Oncology
Interventional
1 Location

Hemangiosarcoma is the most common splenic cancer diagnosed in dogs. The standard of care treatment is splenectomy (surgery) followed by doxorubicin chemotherapy, but long-term survival remains poor. We are continuously looking for additional well-tolerated treatments that may prolong survival for dogs with this disease.

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Investigating a New Treatment for Hemangiosarcoma
Cornell
Cornell
Feline
Interventional
1 Location

Dietary Trial for Cats with IBD or GI Lymphoma

Cornell
Feline
Interventional
1 Location

The clinical signs in some cats with chronic enteropathy (chronic vomiting and/or diarrhea) can be reversed with dietary management using a specially formulated diet. It is not clear why some cats respond to diet, or what the optimal composition of the diet for cats with chronic enteropathy should be. We want to know if diets containing proteins that are selected to minimize immune responses and fortified in Vitamin B12 and natural anti-inflammatory agents (prebiotics and curcumin) are better than conventional diets for cats with chronic enteropathy.

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Dietary Trial for Cats with IBD or GI Lymphoma
Cornell
Cornell
Canine
Observational
1 Location

Sequencing the Genes of Dogs with Acute Myeloid Leukemia

Cornell
Canine
Observational
1 Location

Acute myeloid leukemia is a cancer of the blood. Although uncommon, it is a highly aggressive form of cancer and often kills dogs quickly, particularly because we don’t have many drugs that we can use to treat the leukemia. Great strides have been made in humans with acute myeloid leukemia, which is similar to the disease we see in dogs. However, unlike humans, we know very little about the genetic mutations that underlie acute myeloid leukemia in dogs, which is the goal of this study

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Sequencing the Genes of Dogs with Acute Myeloid Leukemia
Cornell
Cornell
Canine
Interventional
1 Location

Selective Inhibition of Nuclear Export (SINE) and Canine Osteosarcoma

Cornell
Canine
Interventional
1 Location

Osteosarcoma is a common cancer diagnosed in dogs, particularly in large breed dogs. While several chemotherapy protocols have been shown to provide modest management of the onset of metastasis (spread of cancer), we are continuously looking for additional treatments that may extend survival time. Carboplatin is a widely accepted chemotherapy agent used in treatment of osteosarcoma. The results of this study will allow us to determine if dogs can successfully tolerate carboplatin and a new drug called Laverdia-CA1 (verdinexor) in a combination protocol.

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Selective Inhibition of Nuclear Export (SINE) and Canine Osteosarcoma
Midwestern University
Midwestern University
Canine
Observational
1 Location

Performance of a New Point-of-care Rapid Test to Diagnose Pulmonary Coccidioidomycosis

Midwestern University
Canine
Observational
1 Location

Diagnosis of coccidioidomycosis in dogs is challenging due to the fact that the symptoms are not specific for this disease. Coccidioidomycosis can be diagnosed via a biopsy however the most common method is testing for antibodies to the fungus. These tests are often sent to third party labs delaying confirmation of the disease. This study looks to evaluate a potential point of care rapid test which would be able to provide a positive or negative result indicating the presence or absence of antibodies, respectively, within 30-60 minutes. The diagnosis of pulmonary coccidioidomycosis can be difficult because clinical signs overlap with many other respiratory tract disorders and dogs can have positive Valley Fever antibody titers without active clinical infection. Acute phase proteins are useful biomarkers for many other disorders and our hope is to determine whether they can facilitate making a diagnosis of pulmonary coccidioidomycosis in dogs. For additional details or questions please contact Dr. Jaffey (jjaffe@midwestern.edu).

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Performance of a New Point-of-care Rapid Test to Diagnose Pulmonary Coccidioidomycosis
Midwestern University
Midwestern University
Canine
Interventional
1 Location

Efficacy of twice-daily nebulized budesonide for the treatment of canine chronic bronchitis: a pilot study

Midwestern University
Canine
Interventional
1 Location

Canine chronic bronchitis is an inflammatory disease characterized by a cough for > 2 months without another identifiable cause. Dogs with chronic bronchitis have persistent airway neutrophilic inflammation. The foundation of long-term therapy is corticosteroids. Oral prednisone is commonly used but has a litany of possible adverse effects. Inhaled steroids is an alternative to avoid the adverse effects of prednisone but the only available option is fluticasone. This medication is expensive and has variable efficacy. Inhaled budesonide is a medication used in humans to treat a similar airway disorder and is a fraction of the cost. This study aims to investigate the benefit of inhaled budesonide on respiratory tract symptoms in dogs with chronic bronchitis.

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Efficacy of twice-daily nebulized budesonide for the treatment of canine chronic bronchitis: a pilot study