Franklin Animal Clinic

Manley Animal Hospital

MedVet Akron

MedVet Dallas

MedVet Salt Lake City

Quakertown Veterinary Clinic

University of Wisconsin-Madison School of Veterinary Medicine

East Lincoln Animal Hospital

VCA Animal Diagnostic Clinic

Cummings School of Veterinary Medicine Tufts University

PVSEC North Hills

University of Georgia

Anivive Lifesciences

Oncology

Investigational

Lymphoma is one of the most commonly encountered cancers in the dog. The incidence of canine lymphoma has steadily increased with approximately 84 per 10,000 dogs diagnosed each year. This randomized, double-masked, placebo-controlled, GCP pivotal field study is evaluating the effectiveness and safety of verdinexor for the treatment of naïve or first relapse stages II, III and IV lymphoma in client owned dogs. Diagnosis of lymphoma must be confirmed by cytology or biopsy for the dog to be eligible for this study. Dogs will be randomized to receive the investigational veterinary product or a placebo treatment (tablets) to be administered with food twice weekly at least 72 hours apart for 8 weeks.  After receiving treatment in-hospital on Day 0, the dog will be required to return to the study site on Days 7, 14, 28, 42, and 56 for follow up evaluation visits. Owners will be required to report and record abnormal daily observations and dosing using a phone app at home throughout the study.

Canine Lymphoma

If your dog is one of the many every year diagnosed with lymphoma join us in advancing the treatment of canine lymphoma.

Cornell University Hospital for Animals (CUHA)

Cornell

Observational

Infectious

Dr. Gary Whittaker, of the Whittaker Lab, in the Department of Microbiology and Immunology at the Cornell University College of Veterinary Medicine, is continuing the regional study of the feline infectious peritonitis (FIP) virus and how it infects cats. The aim is to reach a better understanding of this virus in order to formulate a successful method of treatment and to work towards a future diagnostic test.

Studying the Genetics of Feline Infectious Peritonitis (FIP)

The aim is to reach a better understanding of this virus in order to formulate a successful method of treatment and to work towards a future diagnostic test.

Hemangiosarcoma is the most common splenic cancer diagnosed in dogs. The standard of care treatment is splenectomy (surgery) followed by doxorubicin chemotherapy, but long-term survival remains poor. We are continuously looking for additional well-tolerated treatments that may prolong survival for dogs with this disease.

Investigating a New Treatment for Hemangiosarcoma

This study will help us to determine if dogs that receive temozolomide and doxorubicin do better than with doxorubicin alone.

Midwestern University Companion Animal Clinic

Midwestern University

Diagnosis of coccidioidomycosis in dogs is challenging due to the fact that the symptoms are not specific for this disease. Coccidioidomycosis can be diagnosed via a biopsy however the most common method is testing for antibodies to the fungus. These tests are often sent to third party labs delaying confirmation of the disease. This study looks to evaluate a potential point of care rapid test which would be able to provide a positive or negative result indicating the presence or absence of antibodies, respectively, within 30-60 minutes. 


The diagnosis of pulmonary coccidioidomycosis can be difficult because clinical signs overlap with many other respiratory tract disorders and dogs can have positive Valley Fever antibody titers without active clinical infection. Acute phase proteins are useful biomarkers for many other disorders and our hope is to determine whether they can facilitate making a diagnosis of pulmonary coccidioidomycosis in dogs.


For additional details or questions please contact Dr. Jaffey (jjaffe@midwestern.edu).

Performance of a New Point-of-care Rapid Test to Diagnose Pulmonary Coccidioidomycosis

Evaluate performance of a new point-of-care rapid test to diagnose pulmonary coccidioidomycosis and determine if acute phase proteins like c-reactive protein, s e r u m amyloid A, procalcitonin have a role to diagnose pulmonary coccidioidomycosis.

View Studies

For Pet Owners

For Veterinarians

Department of Small Animal Clinical Sciences, University of Florida

University of Florida

Schedule

Team

Enrolled pets receive free:

Compensation

Endocrinology

Diabetes mellitus is an important health problem in both dogs and people. Type 1 diabetes (T1D) in people is caused by an attack of the body’s own immune system on cells in the pancreas. Diabetes in dogs is thought to be similar in some ways to T1D in people, but there is still much more to learn about the causes of diabetes in dogs as well as better ways to prevent and treat the disease. The purpose of this study is to learn more about metabolism and immune function in diabetic dogs.

Canine Diabetes

If your dog has diabetes enroll them in our new research study, to help understand the causes of canine diabetes

Immune-mediated hemolytic anemia (IMHA) is a common disease that affects all breeds of dogs and can be fatal. In the severe form of the disease complement activation causes red blood cells to be broken down in the bloodstream.

At present no therapies for IMHA target this complement activation. We have confirmed that an FDA licensed formulation of C1-INH is safe for dogs and effectively inhibits canine complement mediated hemolysis. We hope this will translate into a beneficial effect in dogs with intravascular red cell breakdown due to IMHA.

Complement Inhibition in Canine IMHA

We aim to assess the efficacy of C1-INH for management of intravascular IMHA. This is a double-blinded, randomized controlled trial which means patients will be randomized to receive either C1-INH or a saline placebo infusion three times.

Treatment

Cardiology

Dilated Cardiomyopathy (DCM) is a disease of heart muscle that results in a decreased ability of the heart to pump blood. The prognosis for DCM is often poor, with a less than 50% survival rate one year after clinical signs develop, unless a reversible underlying cause is identified. There is no available cure for Dilated Cardiomyopathy, current techniques focus on extending survival time as long as possible. However the focus of this clinical trial is to evaluate a potential curative treatment for cardiomyopathy in the Doberman Pinscher.

DCM in Dobermans

Has your Doberman been diagnosed with DCM? Help us find the cure.

Internal Medicine

The clinical signs in some cats with chronic enteropathy (chronic vomiting and/or diarrhea) can be reversed with dietary management using a specially formulated diet. It is not clear why some cats respond to diet, or what the optimal composition of the diet for cats with chronic enteropathy should be. We want to know if diets containing proteins that are selected to minimize immune responses and fortified in Vitamin B12 and natural anti-inflammatory agents (prebiotics and curcumin) are better than conventional diets for cats with chronic enteropathy.

Dietary Trial for Cats with IBD or GI Lymphoma

The diagnosis of chronic enteropathy can include cats with chronic vomiting and/or diarrhea, cats with biopsy-diagnosed IBD (inflammatory bowel disease) and cats with small cell GI lymphoma.

Enrolled pets receive:

A new partnership between Anivive Lifesciences and Basepaws has formed to study the genetics of feline diabetes. Cats meeting the study criteria are eligible to receive complimentary genetic testing. Your participation in this study is an opportunity to support scientific exploration of the genes thought to be involved with diabetes. This information will help researchers develop new diagnostic tests, suggest possible preventative measures and explore new treatments for this common feline disease.

Feline Diabetes

Anivive | Basepaws Partnership<br>Join the movement to expand our understanding of the genetics of feline diabetes and help advance cat health.

Osteosarcoma is a common cancer diagnosed in dogs, particularly in large breed dogs. While several chemotherapy protocols have been shown to provide modest management of the onset of metastasis (spread of cancer), we are continuously looking for additional treatments that may extend survival time.  

Carboplatin is a widely accepted chemotherapy agent used in treatment of osteosarcoma. The results of this study will allow us to determine if dogs can successfully tolerate carboplatin and a new drug called Laverdia-CA1 (verdinexor) in a combination protocol.

Selective Inhibition of Nuclear Export (SINE) and Canine Osteosarcoma

Osteosarcoma is a common cancer diagnosed in dogs, particularly in large breed dogs, we are continuously looking for additional treatments that may extend survival time.

Acute myeloid leukemia is a cancer of the blood. Although uncommon, it is a highly aggressive form of cancer and often kills dogs quickly, particularly because we don’t have many drugs that we can use to treat the leukemia. Great strides have been made in humans with acute myeloid leukemia, which is similar to the disease we see in dogs. However, unlike humans, we know very little about the genetic mutations that underlie acute myeloid leukemia in dogs, which is the goal of this study

Sequencing the Genes of Dogs with Acute Myeloid Leukemia

Sequencing the genes in dogs with acute myeloid leukemia

Affenpinscher

Afghan Hound

Airedale Terrier

Akita

Alaskan Malamute

Alaskan Husky

American English Coonhound

American Eskimo Dog (Miniature)

American Eskimo Dog (Standard)

American Eskimo Dog (Toy)

American Foxhound

American Hairless Terrier

American Staffordshire Terrier

American Water Spaniel

Anatolian Shepherd Dog

Australian Cattle Dog

Australian Shepherd

Australian Terrier

Azawakh

Basenji

Basset Hound

Beagle

Bearded Collie

Beauceron

Bedlington Terrier

Belgian Malinois

Belgian Sheepdog

Belgian Tervuren

Bergamasco

Berger Picard

Bernese Mountain Dog

Bichon Frise

Black and Tan Coonhound

Black Russian Terrier

Bloodhound

Bluetick Coonhound

Boerboel

Border Collie

Border Terrier

Borzoi

Boston Terrier

Bouvier des Flandres

Boxer

Boykin Spaniel

Briard

Brittany

Brussels Griffon

Bull Terrier

Bulldog

Bullmastiff

Cairn Terrier

Canaan Dog

Carp Terrier

Cane Corso

Cardigan Welsh Corgi

Cavalier King Charles Spaniel

Cesky Terrier

Chesapeake Bay Retriever

Chihuahua

Chinese Crested Dog

Chinese Shar Pei

Chinook

Chow Chow

Cirneco dell'Etna

Clumber Spaniel

Cocker Spaniel

Collie

Coton de Tulear

Curly-Coated Retriever

Dachshunds

Dalmatian

Dandie Dinmont Terrier

Doberman Pinscher

Dogue de Bordeaux

Dominican Labrador Retriever

English Cocker Spaniel

English Foxhound

English Setter

English Springer Spaniel

English Toy Spaniel

Entlebucher Mountain Dog

Eurohound

Field Spaniel

Finnish Lapphund

Finnish Spitz

Flat-Coated Retriever

French Bulldog

German Pinscher

German Shepherd Dog

German Shorthaired Pointer

German Wirehaired Pointer

Giant Schnauzer

Glen of Imaal Terrier

Golden Retriever

Gordon Setter

Great Dane

Great Pyrenees

Greater Swiss Mountain Dog

Greyhound

Harrier

Akhal Teke

Altai

American Cream Draft

American Saddlebred

Andalusian

Andravida

Appaloosa

Arabian

Australian Stock Horse

Barb

Bashkir Curly

Basotho Pony

Belgian

Black Forest

Breton

Camargue

Campolina

Caspian

Cheju

Chincoteague Pony

Cleveland Bay

Clydesdale

Connemara Pony

Criollo

Crioulo

Dales Pony

Dartmoor Pony

Dutch Warmblood

Eriskay Pony

Exmoor Pony

Falabella

Fell Pony

Finnhorse

Featured

Canine Lymphoma

Studying the Genetics of Feline Infectious Peritonitis (FIP)

Investigating a New Treatment for Hemangiosarcoma

Performance of a New Point-of-care Rapid Test to Diagnose Pulmonary Coccidioidomycosis